THE ROLE OF PEPTIDE-BOND IN CHEMOTACTIC FOR-MET-LEU-PHE-OME FOCUSED BY DEPSIPEPTIDE ANALOGS

Authors
CAVICCHIONI G VERTUANI G SCATTURIN A SPISANI S
Citation
G. Cavicchioni et al., THE ROLE OF PEPTIDE-BOND IN CHEMOTACTIC FOR-MET-LEU-PHE-OME FOCUSED BY DEPSIPEPTIDE ANALOGS, Bioorganic & medicinal chemistry letters, 4(13), 1994, pp. 1551-1554
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
13
Year of publication
1994
Pages
1551 - 1554
Database
ISI
SICI code
0960-894X(1994)4:13<1551:TROPIC>2.0.ZU;2-0
Abstract
The formyl tridepsipeptides HCO-Met-PSI[COO]Leu-Phe-OMe 3, HCO-Met-PSI [COO]Aib-Phe-OMe 4 and HCO-Met-Leu-PSI[COO]Phe-NHBz] 5 were synthesize d in order to investigate the biological consequences arising from int roduction of an ester bond at various positions in the chemotactic tri peptides. While analogs 3 and 4 were found lacking in biological activ ity, stressing an essential role for peptide bond at position 2, compo und 5 showed to retain activity.