MAPPING THE MELATONIN RECEPTOR .2. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF INDOLE DERIVED MELATONIN ANALOGS WITH RESTRICTED CONFORMATIONS OF THE C-3 AMIDOETHANE SIDE-CHAIN

Authors
GARRATT PJ VONHOFF S ROWE SJ SUGDEN D
Citation
Pj. Garratt et al., MAPPING THE MELATONIN RECEPTOR .2. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF INDOLE DERIVED MELATONIN ANALOGS WITH RESTRICTED CONFORMATIONS OF THE C-3 AMIDOETHANE SIDE-CHAIN, Bioorganic & medicinal chemistry letters, 4(13), 1994, pp. 1559-1564
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
13
Year of publication
1994
Pages
1559 - 1564
Database
ISI
SICI code
0960-894X(1994)4:13<1559:MTMR.S>2.0.ZU;2-Y
Abstract
A number of indole derived melatonin analogues have been prepared with the C-3 amidoethane side chain partially constrained by incorporation in a ring. The biological activity has been correlated with the confo rmation of the ''side chain'', the nature of the N-acylating group, an d the spatial distance between the methoxyl and amide functions.