ASYMMETRIC-SYNTHESIS OF ENANTIOMERICALLY PURE 4'-FLUOROALKYL-2',3'-DIDEOXY NUCLEOSIDES

Authors
BRAVO P MELE A SALANI G VIANI F
Citation
P. Bravo et al., ASYMMETRIC-SYNTHESIS OF ENANTIOMERICALLY PURE 4'-FLUOROALKYL-2',3'-DIDEOXY NUCLEOSIDES, Bioorganic & medicinal chemistry letters, 4(13), 1994, pp. 1577-1580
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
13
Year of publication
1994
Pages
1577 - 1580
Database
ISI
SICI code
0960-894X(1994)4:13<1577:AOEP4>2.0.ZU;2-2
Abstract
Elaboration of (fluoromethyl)-2-[(4-methylphenylsulphinyl)methyl] oxir ane (5), deriving from p-tolylmethyl sulphoxide (2), ethyl fluoroaceta te (3) and diazomethane, to 4'-fluoromethyl lactol (10) followed by co ndensation with the activated thymine and reductive debenzylation allo wed the obtainment of 4'-fluoromethyl-2',3'-dideoxythymidine (1).