C. Li et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF VINYL SULFONE BASED ANTICANCER AGENTS, Bioorganic & medicinal chemistry letters, 4(13), 1994, pp. 1585-1590
Several vinyl sulfone based substrates exhibited excellent in vitro ac
tivity against the HT-29 colon cancer cell line and also demonstrated
in vitro differential cytotoxicity against ras transformed mt kidney e
pithelial cell lines. Evaluation of three agents in animal trials reve
aled no anticancer activity.