PREPARATION AND ANTITUMOR-ACTIVITY OF [N-ALKYL-ALA(2)]RA-VII, ANTITUMOR CYCLIC HEXAPEPTIDE

Authors
HITOTSUYANAGI Y SUZUKI J TAKEYA K ITOKAWA H
Citation
Y. Hitotsuyanagi et al., PREPARATION AND ANTITUMOR-ACTIVITY OF [N-ALKYL-ALA(2)]RA-VII, ANTITUMOR CYCLIC HEXAPEPTIDE, Bioorganic & medicinal chemistry letters, 4(13), 1994, pp. 1633-1636
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
13
Year of publication
1994
Pages
1633 - 1636
Database
ISI
SICI code
0960-894X(1994)4:13<1633:PAAO[A>2.0.ZU;2-P
Abstract
A number of [N-alky-Ala-2]RA-VII derivatives have been prepared from R A-VII (1) and evaluated for in vitro antitumor activity against P388 a nd KB cells, and partly for in vivo anti-P388 activity. All analogues retained significant cytotoxicity, and N-prenyl derivative (2j) showed more promising in vivo activity than 1.