CYCLOHEPTIMIDAZOLE BASED ANGIOTENSIN-II RECEPTOR ANTAGONISTS - 4,5,6,7-TETRAHYDRO-8-CARBOXYMETHYLIDENE CYCLOHEPTIMIDAZOLES

Authors
UEYAMA N YANAGISAWA T BABA H KUROIWA K HAYASHI H SONEGAWA M TOMIYAMA T
Citation
N. Ueyama et al., CYCLOHEPTIMIDAZOLE BASED ANGIOTENSIN-II RECEPTOR ANTAGONISTS - 4,5,6,7-TETRAHYDRO-8-CARBOXYMETHYLIDENE CYCLOHEPTIMIDAZOLES, Bioorganic & medicinal chemistry letters, 4(13), 1994, pp. 1637-1642
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
13
Year of publication
1994
Pages
1637 - 1642
Database
ISI
SICI code
0960-894X(1994)4:13<1637:CBARA->2.0.ZU;2-8
Abstract
etrahydro-8-carboxymethylidene-cycloheptimidazoles were synthesized as potential angiotensin II (AII) receptor antagonists. One of these, 10 b, KT 3-866, showed a pD'2 value of 9.91 and was about 5 times more po tent than KT 3-671 in an vivo study and had long lasting inhibitory ac tion on AII-induced pressor response in rats at a dose of 0.3 mg/kg.