SUBCORTICAL NEUMANN DEMENTIA FINDINGS IN SPECT AND MRI

A 36 year-old patient presented with a dementia of frontal type, gait disturbances, incontinence and a pseudo-bulbar palsy, which caused dea th at age 40. Brain biopsy of the frontal lobe showed an extensive dee p subcortical gliosis. A high level of GFAP was detected by immunoblot ting in the biopsy. Clinical and neuropathological observations are si milar to cases described as Neumann Progressive Subcortical Gliosis. S ingle Photon Emission Computer Tomography showed a bilateral frontotem poral hypoperfusion, and Magnetic Resonance Imaging large periventricu lar and subcortical hyperintensities in both hemispheres, the brainste m and the cerebellum. The hyperintensities on T2-weighted MR images mi ght be related to the intense gliosis. The contribution of such imagin g data to diagnosis must be confirmed by other clinico-pathological ca ses.