EVALUATION OF CHEMOPREVENTIVE EFFECTS OF BETEL LEAF ON THE GENOTOXICITY OF PAN-MASALA

Authors
TRIVEDI AH PATEL RK RAWAL UM ADHVARYU SG BALAR DB
Citation
Ah. Trivedi et al., EVALUATION OF CHEMOPREVENTIVE EFFECTS OF BETEL LEAF ON THE GENOTOXICITY OF PAN-MASALA, Neoplasma, 41(3), 1994, pp. 177-181
Citations number
33
Categorie Soggetti
Oncology
Journal title
Neoplasma → ACNP
ISSN journal
00282685
Volume
41
Issue
3
Year of publication
1994
Pages
177 - 181
Database
ISI
SICI code
0028-2685(1994)41:3<177:EOCEOB>2.0.ZU;2-3
Abstract
The antigenotoxic efect of the aqueous extract of betel leaf (BL-ext.) against the pan masala was tested with the help of cytogenetic endopo ints like chromosome aberration(CA) and sister chromatid exchange (SCE ) utilizing Chinese hamster ovary (CHO) cells. Compared to the culture s treated with aqueous extract of pan masala alone, a reduction in CA and SCE frequencies in CHO cells was observed following a combined tre atment with pan masala (with or without tobacco) extract and BL-ext. T he protective effect of BL-ext. against the genomic damage caused by p an masala was statistically significant only after treating the cells for a longer period.