DIETARY FISH OILS DECREASE BRADYKININ-INDUCED SECRETION IN RAT DISTALCOLON

This study aimed to determine whether or not dietary fish oils can mod ulate colonic chloride (Cl-) secretion induced by bradykinin, an infla mmatory mediator, via the synthesis of prostaglandin E(2) (PGE(2)) in a mucosal preparation of rat distal colon. Three diets containing 10 w t% fat composed of different oils, 100% safflower oil, and 40% safflow er oil plus 60% sardine oil (rich in eicosapentaenoic acid) and 60% tu na oil (rich in docosahexaenoic acid), respectively, were administered for 21 d to rats. The fish oil supplements did not affect the rate of growth. Bradykinin-induced Cl- secretion was monitored as the change in the short-circuit current (I-SC) across a mucosal preparation of th e distal colon. The increase in I-SC during 10 min in response to brad ykinin 10(-7) M was significantly lower for the fish oil-fed rats than for the safflower oil-fed ones. The production of PGE(2) in response to bradykinin was drastically decreased in the colonic mucosa of fish oil-fed rats compared to that in safflower oil-fed ones. The results s uggest that fish oil supplements are valuable for preventing prostagla ndin-induced intestinal secretion. Copyright (C) 1997 Elsevier Science Inc.