SPATIAL DISCONTINUITIES IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 QUASI-SPECIES DERIVED FROM EPIDERMAL LANGERHANS CELLS OF A PATIENT WITH AIDSAND EVIDENCE FOR DOUBLE INFECTION

Authors
SALA M ZAMBRUNO G VARTANIAN JP MARCONI A BERTAZZONI U WAINHOBSON S
Citation
M. Sala et al., SPATIAL DISCONTINUITIES IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 QUASI-SPECIES DERIVED FROM EPIDERMAL LANGERHANS CELLS OF A PATIENT WITH AIDSAND EVIDENCE FOR DOUBLE INFECTION, Journal of virology, 68(8), 1994, pp. 5280-5283
Citations number
23
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
68
Issue
8
Year of publication
1994
Pages
5280 - 5283
Database
ISI
SICI code
0022-538X(1994)68:8<5280:SDIHTQ>2.0.ZU;2-Y
Abstract
A nonhomogeneous spatial distribution of human immunodeficiency virus type 1 quasispecies was observed for epidermal Langerhans cells purifi ed from skin patches taken from a patient with AIDS soon after death. Each patch presented a unique collection of sequences, distinct from t hose of juxtaposed patches or those derived from the other leg. Infect ion of Langerhans cells by virus from underlying T cells in the dermis might explain this partition. The analysis revealed the presence of t wo distinct cocirculating viral strains, indicating double infection.