NOVEL REDUCTION AND HYDROXYLATION PRODUCTS FORMED BY ASPERGILLUS-FUMIGATUS FROM REICHSTEIN SUBSTANCE-S

Authors
GARAI S MAHATO SB
Citation
S. Garai et Sb. Mahato, NOVEL REDUCTION AND HYDROXYLATION PRODUCTS FORMED BY ASPERGILLUS-FUMIGATUS FROM REICHSTEIN SUBSTANCE-S, Steroids, 62(2), 1997, pp. 253-257
Citations number
16
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Steroids → ACNP
ISSN journal
0039128X
Volume
62
Issue
2
Year of publication
1997
Pages
253 - 257
Database
ISI
SICI code
0039-128X(1997)62:2<253:NRAHPF>2.0.ZU;2-8
Abstract
Fermentation of Reichstein's Substance S with Aspergillus fumigatus (A M-21) under aerobic conditions yielded 17 alpha, 21-dihydroxy-5 alpha- pregn-1-ene-3,20-dione, 17 alpha,20 alpha,21-trihydroxy-5 alpha-pregn- 1-en-3-one, 6 beta,17 alpha,21-trihydroxypregn-4-en-3,20-dione, 15 bet a,17 alpha,21-trihydroxy-5 alpha-pregnane-3,20-dione, and 15 beta,17 a lpha,20 alpha,21-tetrahydroxy-5 alpha-pregn-1-en-3-one. Each microbial metabolite was characterized by spectroscopic methods, C-13 NMR chemi cal shifts. (C) 1997 by Elsevier Science Inc.