THE MURINE HOMOLOGS OF THE HUNTINGTON DISEASE GENE (HDH) AND THE ALPHA-ADDUCIN GENE (ADD1) MAP TO MOUSE CHROMOSOME-5 WITHIN A REGION OF CONSERVED SYNTENY WITH HUMAN-CHROMOSOME 4P16.3

Huntington disease (HD) is a severe autosomal dominant neurodegenerati ve disorder associated with a novel gene (IT15). Recently, we reported the cloning of Hdh, the murine homologue of IT15. Here, using an inte rspecific backcross, we have mapped both Hdh and the mouse homologue o f human alpha-adducin (Add1), a membrane-associated cytoskeletal prote in gene. Both of these genes map in the same position on mouse chromos ome 5 in a region associated with ancestral chromosomal rearrangements and show no recombination with D5H4543, D5H4S115, and D5H4S62, the mu rine homologues of D4543, D4S115, and D4S62, respectively. Further map ping studies of humans, mice, and other mammalian species should revea l the nature of the rearrangements affecting this chromosomal segment during mammalian evolution. (C) 1994 Academic Press, Inc.