SPECT WITH HMPAO COMPARED TO PET WITH FDG IN HUNTINGTON DISEASE

Citation
H. Boecker et al., SPECT WITH HMPAO COMPARED TO PET WITH FDG IN HUNTINGTON DISEASE, Journal of computer assisted tomography, 18(4), 1994, pp. 542-548
Citations number
52
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
03638715
Volume
18
Issue
4
Year of publication
1994
Pages
542 - 548
Database
ISI
SICI code
0363-8715(1994)18:4<542:SWHCTP>2.0.ZU;2-8
Abstract
Objective: It is the aim of this study to compare the performance of 9 9(m)Tc-d, l-hexamethylpropyleneamine oxime (HMPAO) SPECT with that of [F-18]fluorodeoxyglucose (FDG) PET in detecting striatal dysfunction a s it occurs in Huntington disease (HD). Materials and Methods: For the determination of regional cerebral glucose consumption, the PET camer a PC-4096 was used; the cerebral uptake of HMPAO was measured using th e three-head SPECT camera TRIAD. Eight patients with manifest HD, seve n subjects at risk for HD, and nine normal individuals were included i n the study. In both modalities data evaluation was performed using ca udate-to-whole-slice (C/S) ratios. The patients' data were compared to 95% confidence intervals determined in the nine controls. Results: Th e PET and SPECT CIS values correlated significantly (n = 24; r = 0.87; p < 0.0001). The CIS values were significantly reduced in PET in all eight and in SPECT in seven of the eight HD patients studied. Five of the seven at-risk subjects had normal CIS values in PET and SPECT, one showed reduced C/S values in both diagnostic methods, and the remaini ng at-risk individual showed a reduced C/S value in PET only. Thus, co ncordant results between PET and SPECT were obtained in seven of eight patients and six of seven at-risk subjects studied, corresponding to an 87% accuracy of SPECT in the detection of striatal dysfunction as c ompared to the ''gold standard'' PET. Conclusion: With use of a multid etector camera, HMPAO-SPECT comes near the performance of FDG-PET in t he diagnosis of striatal dysfunction as it occurs in HD.