PATTERN OF GONADOTROPIN-SECRETION IN PATIENTS WITH HYPERANDROGENAEMICAMENORRHEA BEFORE AND AFTER OVARIAN WEDGE RESECTION

The follow-up of androgen and gonadotrophin concentrations after ovari an wedge resection is reported in two patients with hyperandrogenaemic amenorrhoea. Elevated testosterone concentrations decreased immediate ly and androstenedione after 3 months. In a patient with polycystic ov arian disease, luteinizing hormone (LH) amplitudes were reduced in the presence of unchanged pulse frequency. Small decreases in mean LH bas eline values were accompanied by increases in follicle stimulating hor mone concentrations. Our data provide evidence that reduction of eleva ted ovarian androgen concentrations leads (directly or indirectly) to a decrease of exaggerated LH pulse amplitude in patients with hyperand rogenaemic amenorrhoea.