INVESTIGATION OF SYNERGISM WITH COMBINATIONS OF DIBROMOPROPAMIDINE ISETHIONATE OR PROPAMIDINE ISETHIONATE AND POLYMYXIN-B

Combinations of polymyxin B and dibromopropamidine isethionate exhibit ed synergistic inhibitory and bactericidal activity against Pseudomona s aeruginosa, Enterobacter cloacae, Proteus mirabilis, Escherichia col i and Staphylococcus aureus. Similar results were obtained with polymy xin B plus propamidine combinations except that propamidine was not as active as dibromopropamidine and the combination of polymyxin B plus propamidine against S. aureus only had additive activity. The antibact erial agents were tested in solutions and in a cream formulation. The findings indicate a potential for the use of selected combinations of these antibacterial agents in the treatment of wound and superficial e ye infections.