THE RECOGNITION OF A DIARYLIMINE AS A METABONATE PRODUCED DURING INCUBATION OF N-BENZYL-4-CHLOROANILINE WITH HEPATIC-MICROSOMAL PREPARATIONS

Authors
LOW CM ULGEN M GORROD JW
Citation
Cm. Low et al., THE RECOGNITION OF A DIARYLIMINE AS A METABONATE PRODUCED DURING INCUBATION OF N-BENZYL-4-CHLOROANILINE WITH HEPATIC-MICROSOMAL PREPARATIONS, Journal of Pharmacy and Pharmacology, 46(7), 1994, pp. 585-590
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of Pharmacy and Pharmacology → ACNP
ISSN journal
00223573
Volume
46
Issue
7
Year of publication
1994
Pages
585 - 590
Database
ISI
SICI code
0022-3573(1994)46:7<585:TROADA>2.0.ZU;2-0
Abstract
Evidence is presented for the formation of N-benzylidene-4-chloroanili ne as a metabonate during the metabolism of N-benzyl-4-chloroaniline. Control studies suggest that the diarylimine is formed as a chemical a rtifact from the debenzylation products (benzaldehyde and 4-chloroanil ine). This novel observation indicates a possible pathway to amide for mation from N-benzylanilines via diarylimines as intermediates.