DECREASED CYCLOSPORINE-A ABSORPTION AFTER TREATMENT WITH GOLYTELY LAVAGE SOLUTION IN RATS

Recently we observed a case in which the cyclosporin A absorption decr eased after treatment with GoLytely lavage solution in a kidney transp lant patient. In this study, we confirmed the decrease of the blood co ncentration of cyclosporin A after oral administration by GoLytely (Ma crogol 3350) based on experiments with rats. The peak blood cyclospori n A concentration, and the area under the blood drug concentration-tim e curve from 0 to 24 h in the GoLytely-administered group were signifi cantly lower than the control group. In the case of gastrointestinal d ysfunction such as diarrhoea, or in treatment with laxatives such as G oLytely lavage solution, whole blood cyclosporin levels must be carefu lly monitored, and intravenous cyclosporin A may be more suitable for providing adequate immunosuppression.