AUTOANTIBODIES TO MYELIN BASIC-PROTEIN ARE NOT PRESENT IN THE SERUM AND CSF OF MS PATIENTS

Myelin basic protein (MBP) is one of the main constituents of the CNS myelin sheaths, and an autoimmune response directed against MBP may be crucial in the demyelination process in patients with multiple sclero sis (MS). In this study sera and cerebrospinal fluid (CSF) from 25 MS patients, 25 patients with other neurological diseases and 16 healthy controls were examined for antibodies against MBP by using radio immun oblot, western blot, radio immunoassay and enzyme-linked immunosorbant assay. No evidence for the presence of antibodies to MBP was found in sera or CSFs in either the MS patients, or in the control groups test ed.