ENZYMATIC RESOLUTIONS OF HETEROCYCLIC ALCOHOLS

Authors
HONIG H SHI NY POLANZ G
Citation
H. Honig et al., ENZYMATIC RESOLUTIONS OF HETEROCYCLIC ALCOHOLS, Biocatalysis, 9(1-4), 1994, pp. 61-69
Citations number
25
Categorie Soggetti
Biology,"Biothechnology & Applied Migrobiology
Journal title
Biocatalysis → ACNP
ISSN journal
08864454
Volume
9
Issue
1-4
Year of publication
1994
Pages
61 - 69
Database
ISI
SICI code
0886-4454(1994)9:1-4<61:EROHA>2.0.ZU;2-2
Abstract
The butyrates and acetates of heterocyclic alcohols like 3 - hydroxy t etrahydrofuran and - pyran, 3- and 4 - chromanol as well as the corres ponding sulfur heterocycles were hydrolyzed using lipase from Candida rugosa (CRL) and from Pseudomonas cepacia. (PCL). Poor to excellent en antioselectivities were obtained depending on the structure of the sub strates. An electrostatic amendment to the steric substrate model for PCL is proposed.