LIPASE-CATALYZED RESOLUTION OF (+ -)-2-SUBSTITUTED 1-PROPANOL DERIVATIVES POSSESSING AN AROMATIC RING/

Authors
AKITA H NOZAWA M UMEZAWA I NAGUMO S
Citation
H. Akita et al., LIPASE-CATALYZED RESOLUTION OF (+ -)-2-SUBSTITUTED 1-PROPANOL DERIVATIVES POSSESSING AN AROMATIC RING/, Biocatalysis, 9(1-4), 1994, pp. 79-87
Citations number
14
Categorie Soggetti
Biology,"Biothechnology & Applied Migrobiology
Journal title
Biocatalysis → ACNP
ISSN journal
08864454
Volume
9
Issue
1-4
Year of publication
1994
Pages
79 - 87
Database
ISI
SICI code
0886-4454(1994)9:1-4<79:LRO(-1>2.0.ZU;2-R
Abstract
For the purpose of the chiral synthesis of natural products, lipase-ca talyzed kinetic resolutions of three types of 2-substituted 1-propanol derivatives (each having an aromatic ring) was investigated. In every case, chiral recognition of the primary alcohol unit took place to pr ovide the corresponding alcohols and the acetates in high optical puri ty. The (2S,3S)-5-aryl-2-methyl-3-hydroxy-4E-pentenol 5 was formally c onverted into the antibiotic, (-)-oudemansin X.