AN AUTOMATED LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY SYSTEM COUPLED ONLINE WITH MICRODIALYSIS FOR THE IN-VIVO ANALYSIS OF CONTRAST AGENTS

Authors
MICHELSEN P PETTERSSON G
Citation
P. Michelsen et G. Pettersson, AN AUTOMATED LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY SYSTEM COUPLED ONLINE WITH MICRODIALYSIS FOR THE IN-VIVO ANALYSIS OF CONTRAST AGENTS, Rapid communications in mass spectrometry, 8(7), 1994, pp. 517-520
Citations number
5
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
8
Issue
7
Year of publication
1994
Pages
517 - 520
Database
ISI
SICI code
0951-4198(1994)8:7<517:AALMSC>2.0.ZU;2-Y
Abstract
An automated high-performance liquid chromatography (HPLC)/mass spectr ometry instrument coupled on-line with a microdialysis probe is descri bed for the analysis of contrast agents in biological fluids. This sys tem is used for pharmacokinetic and structure elucidation studies of c ontrast agents used in X-ray and magnetic resonance imaging investigat ions. Additionally an LC/MS system for the direct analysis of urine, t hat obviates the need for conventional sample clean-up, is described.