Six hundred and ninety-six patients, from among a total of 1868 cases,
were diagnosed as having gastric cancer, and underwent surgical treat
ment at this Medical Institution, between 1972 and 1992. Eighteen pati
ents (2.6 %) died of recurrent disese, four (0.6%) tumors being mucosa
l, and fourteen (2.0%) submucosal, in accordance with depth of invasio
n. The clinico-pathological findings were analysed to clarify the risk
factors of recurrence in patients with early gastric cancer, as follo
ws: (a) submucosal invasion, (b) mixed type II a + II c in gross appea
rance, (c) tumor size more than 40 mm in diameter. In mucosal cancers,
recurrance occurred in patients with lymph-vessel invasion and lymph-
node metastasis. In terms of the site of the recurrent lesion, the pat
ients had predominantly hepatic recurrence. We conclude that there are
specific factors related to the increased risk of recurrence, that ca
n be evaluated pre-operatively. By identifying the risk factors of rec
urrence, we can optimize the therapeutic approach to these patients.