RECOVERY FROM DEPRESSION AFTER ELECTROCONVULSIVE-THERAPY IS ACCOMPANIED BY EVIDENCE OF INCREASED TETRAHYDROBIOPTERIN-DEPENDENT HYDROXYLATION

Authors
ANDERSON DN WILKINSON AM ABOUSALEH MT BLAIR JA
Citation
Dn. Anderson et al., RECOVERY FROM DEPRESSION AFTER ELECTROCONVULSIVE-THERAPY IS ACCOMPANIED BY EVIDENCE OF INCREASED TETRAHYDROBIOPTERIN-DEPENDENT HYDROXYLATION, Acta psychiatrica Scandinavica, 90(1), 1994, pp. 10-13
Citations number
23
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
Acta psychiatrica Scandinavica → ACNP
ISSN journal
0001690X
Volume
90
Issue
1
Year of publication
1994
Pages
10 - 13
Database
ISI
SICI code
0001-690X(1994)90:1<10:RFDAEI>2.0.ZU;2-M
Abstract
Serum phenylalanine and tyrosine levels were measured in 26 patients w ith severe depression before and after receiving electroconvulsive the rapy. The phenylalanine:tyrosine [P:T] ratio declined significantly fo r those responding to treatment but not for nonresponders. These findi ngs are discussed in relation to tetrahydrobiopterin, the essential co factor for the formation of noradrenaline, dopamine and serotonin and the hydroxylation of phenylalanine to tyrosine.