H. Mizuguchi et al., GLIAL EXTRACELLULAR-MATRIX MODULATES GAMMA-GLUTAMYL-TRANSPEPTIDASE ACTIVITY IN CULTURED BOVINE BRAIN CAPILLARY AND BOVINE AORTIC ENDOTHELIAL-CELLS, Brain research, 651(1-2), 1994, pp. 155-159
Glial extracellular matrix (ECM) elevated gamma-glutamyl transpeptidas
e (gamma-GTP) activity in cultured bovine brain capillary and aortic e
ndothelial cells (BBCEC, BAEC). In particular, the ECM of glial cells
cultured with the conditioned medium of BAEC (BAEC CM) dramatically el
evated gamma-GTP activity in BBCEC and BAEC. The ECM of glial cells cu
ltured with BBCEC CM also had a marked effect. The ECM of 3T3 cells cu
ltured with BAEC CM, and the ECM of glial cells cultured with 3T3 CM h
ad no effect. Glial CM had no effect on gamma-GTP activity in BBCEC an
d BAEC. These findings indicate that gamma-GTP activity in endothelial
cells (EC) is modulated by glial ECM, and that the factor of ECM that
affects gamma-GTP activity in EC arises from the interaction between
glial cells and EC.