SYNTHESIS OF A POTENTIAL ANTIVIRAL COMPOUND - 5-BROMOETHYNYL-2'-DEOXYURIDINE

Authors
EGER K JALALIAN M SCHMIDT M
Citation
K. Eger et al., SYNTHESIS OF A POTENTIAL ANTIVIRAL COMPOUND - 5-BROMOETHYNYL-2'-DEOXYURIDINE, Tetrahedron, 50(28), 1994, pp. 8371-8380
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
28
Year of publication
1994
Pages
8371 - 8380
Database
ISI
SICI code
0040-4020(1994)50:28<8371:SOAPAC>2.0.ZU;2-4
Abstract
5-Bromoethynyluracil and its deoxyriboside can be prepared in good yie lds starting from dibromovinyluracil, which is accesible by literature methods. 5-Bromoethynyl-deoxyuridine is less effective against HSV-I than E-(bromovinyl)deoxyuridine but, similar to BVDU, seems to exhibit a certain selectivity toward HSV-1. Molecular calculations prove the spatial similarity of both compounds.