RAPAMYCIN SYNTHETIC STUDIES .2. ELABORATION OF THE C(10)-C(26) PERIMETER

Authors
SMITH AB MALECZKA RE LEAZER JL LEAHY JW MCCAULEY JA CONDON SM
Citation
Ab. Smith et al., RAPAMYCIN SYNTHETIC STUDIES .2. ELABORATION OF THE C(10)-C(26) PERIMETER, Tetrahedron letters, 35(28), 1994, pp. 4911-4914
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
28
Year of publication
1994
Pages
4911 - 4914
Database
ISI
SICI code
0040-4039(1994)35:28<4911:RSS.EO>2.0.ZU;2-Q
Abstract
The C(10)-C(26) subunit of the potent immunomodulator rapamycin has be en constructed via a highly convergent approach, exploiting palladium- mediated sigma-bond formation to generate the sensitive triene moiety.