SYNTHESIS OF BOTH ENANTIOMERS OF C-2 SYMMETRICAL TRANS-2,5-BIS(HYDROXYMETHYL)PYRROLIDINE - LIPASE-MEDIATED SEQUENTIAL KINETIC RESOLUTIONS

Authors
SIBI MP LU JL
Citation
Mp. Sibi et Jl. Lu, SYNTHESIS OF BOTH ENANTIOMERS OF C-2 SYMMETRICAL TRANS-2,5-BIS(HYDROXYMETHYL)PYRROLIDINE - LIPASE-MEDIATED SEQUENTIAL KINETIC RESOLUTIONS, Tetrahedron letters, 35(28), 1994, pp. 4915-4918
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
28
Year of publication
1994
Pages
4915 - 4918
Database
ISI
SICI code
0040-4039(1994)35:28<4915:SOBEOC>2.0.ZU;2-V
Abstract
Lipase mediated sequential kinetic resolution has been employed to giv e both enantiomers of trans-2,5-bis(hydroxymethyl)pyrrolidine in optic ally pure form. The effect of different parameters on the ee and yield s in these resolutions are also reported.