SYNTHESIS OF NOVEL PHOSPHONATE ANALOG OF KDO AS A TOOL FOR THE DESIGNOF POTENT INHIBITORS FOR LIPOPOLYSACCHARIDE BIOSYNTHESIS

Authors
SHEFFERDEENOOR S BELAKHOV V BAASOV T
Citation
S. Shefferdeenoor et al., SYNTHESIS OF NOVEL PHOSPHONATE ANALOG OF KDO AS A TOOL FOR THE DESIGNOF POTENT INHIBITORS FOR LIPOPOLYSACCHARIDE BIOSYNTHESIS, Tetrahedron letters, 35(28), 1994, pp. 5077-5080
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
28
Year of publication
1994
Pages
5077 - 5080
Database
ISI
SICI code
0040-4039(1994)35:28<5077:SONPAO>2.0.ZU;2-O
Abstract
The new phosphonate analogue 3 of 2-deoxy-beta-Kdo (2) was prepared in a stereospecific manner via intramolecular C-C bond formation. X-Ray structure analysis and NMR studies of the cyclyzation product establis hed the twist-boat conformation of the pyranose ring with alpha-anomer ic configuration of the phosphonate linkage.