R. Allin et al., EFFECT OF AMYGDALOID KINDLING ON RAT STRIATAL DOPAMINE D-1-RECEPTORS AND D-2-RECEPTORS, Neurochemical research, 19(7), 1994, pp. 827-831
The effect of kindling on dopaminergic (DA) neurotransmission was asse
ssed by measuring dopamine D-1- and D-2-receptor binding in the dorsal
and ventral striatum of rats either 2 hours (short-term) or 3-4 weeks
(long-term) after the last kindled seizure. Kindling did not have any
significant long-term effect on DA D-2-receptor K-d or B-max values i
n the dorsal or ventral striatum or on DA D-1-receptor parameters in t
he dorsal striatum. The short-term effect of kindled seizures was to a
bolish the asymmetry in DA D2(-)receptor density observed in the dorsa
l striatum of control rats. DA D-1-receptor density was also increased
in the dorsal striatum contralateral to the kindled amygdala of shore
-term rats. The short-term effects support the notion that limbic seiz
ures can modify the lateral imbalance of DA activity in the striatum.