The absence of laboratory tests and clear criteria to identify homogen
eous (sub)groups in patients presenting with unexplained fatigue, and
to assess clinical status and disability in these patients, calls for
further assessment methods. In the present study, a multi-dimensional
approach to the assessment of chronic fatigue syndrome (CFS) is evalua
ted. Two-hundred and ninety-eight patients with CFS completed a set of
postal questionnaires that assessed the behavioural, emotional, socia
l, and cognitive aspects of CFS. By means of statistical analyses nine
relatively independent dimensions of CFS were identified along which
CFS-assessment and CFS-research can be directed. These dimensions were
named: psychological well-being, functional impairment in daily life,
sleep disturbances, avoidance of physical activity, neuropsychologica
l impairment, causal attributions related to the complaints, social fu
nctioning, self-efficacy expectations, and subjective experience of th
e personal situation. A description of the study sample on these dimen
sions is presented.