A THEORY FOR THE PRIMARY AND SECONDARY DRYING STAGES OF THE FREEZE-DRYING OF PHARMACEUTICAL CRYSTALLINE AND AMORPHOUS SOLUTES - COMPARISON BETWEEN EXPERIMENTAL-DATA AND THEORY

Authors
LIAPIS AI BRUTTINI R
Citation
Ai. Liapis et R. Bruttini, A THEORY FOR THE PRIMARY AND SECONDARY DRYING STAGES OF THE FREEZE-DRYING OF PHARMACEUTICAL CRYSTALLINE AND AMORPHOUS SOLUTES - COMPARISON BETWEEN EXPERIMENTAL-DATA AND THEORY, Separations technology, 4(3), 1994, pp. 144-155
Citations number
NO
Categorie Soggetti
Engineering, Chemical","Chemistry Analytical
Journal title
Separations technology → ACNP
ISSN journal
09569618
Volume
4
Issue
3
Year of publication
1994
Pages
144 - 155
Database
ISI
SICI code
0956-9618(1994)4:3<144:ATFTPA>2.0.ZU;2-Y
Abstract
A theory is constructed to describe quantitatively the dynamic behavio r of the primary and secondary drying stages of the freeze-drying of p harmaceutical crystalline and amorphous solutes. Experimental data for the freeze-drying of cloxacillin monosodium salt and skim milk are ob tained using a pilot freeze-dryer The comparison of the theoretical re sults with the experimental data shows that the agreement between expe riment and theory is good.