THE SECONDARY METABOLITES OF AFF SAMADERA SAC-2825 - AN AUSTRALIAN SIMAROUBACEAE WITH UNUSUAL CHEMISTRY

The phytochemical analysis of two collections of a new species (SAC-28 25), tentatively assigned as aff. Samadera bidwillii (Simaroubaceae), has yielded a limonoid (limonin), a quassinoid (2'-acetoxy-glaucarubin ), three alkaloids 'xi-acetoxyundecanyl)-1-acetoxymethyl-4-quinolone, 1-methoxy-10-methyl-acridan-9-one and 1,8-dihydroxyacridan-9-one] and seven bicycle-octane type lignans [(-)-sesamin, (-)-episesamin, farges in, neofargesin, (-)-kobusin, (-)-epieudesmin and (-)-eudesmin]. The 4 -quinolone alkaloid appears to be novel. The metabolites identified ar e collectively typical of the Rutales, but have a biosynthetic range n ever previously found together in a single species. Particularly notew orthy is the cooccurrence of limonoids and quassinoids in the same pla nt, which is currently unique to SAG-2825. Copyright (C) 1997 Elsevier Science Ltd.