ROLE OF HELICOBACTER-PYLORI IN CIRRHOTIC-PATIENTS WITH PEPTIC-ULCER -A SEROLOGICAL STUDY

Helicobacter pylori was found to be a promoter factor of peptic ulcer that has an incidence higher in patients with hepatic cirrhosis. To cl arify the role between H. pylori and peptic ulcer in patients with hep atic cirrhosis, a serological test (ELISA test, HEL-p, AMRAD, Australi a), was used to measure the presence of H. pylori of patients with hep atic cirrhosis. Within two years, 108 cirrhotic patients who had recei ved a panendoscopic examination were enrolled in this study. There wer e 79 males and 27 females with a mean age of 53.2 years. Sixty-four ca ses had positive serum HBsAg and 44 had negative serum. The results sh owed that the prevalence of Helicobacter pylori in cirrhosis was 43.5% (47/108). There was no difference of HEL-p-positive rate between pept ic ulcer and normal gastroduodenal mucosa (45.2% vs 46.1%, P > 0.05). According to this study, there appears to be no relation between pepti c ulcer and H. pylori in patients with hepatic cirrhosis. The etiology of peptic ulcer in cirrhotic patients need further study.