Gerald Klerman (1928-1992) made substantial contributions to diagnosis
and classification in psychiatry during a time of great change. He un
derstood and appreciated the importance of descriptive, biological, ps
ychoanalytic, social, interpersonal, and behavioral approaches and was
uniquely able to integrate them cogently. He demanded that theories a
nd hypotheses be tested empirically, and he spearheaded many key scien
tific research programs directed toward this goal, including the Clini
cal Studies of the National Institute of Mental Health Program on the
Psychobiology of Depression. This article provides an overview of his
contributions.