LOSS AND ANTI-EBNA-1 DURING ACTIVE HEPATITIS-B VIRUS-INFECTION - A DIAGNOSTIC PROBLEM AND INDICATION OF HBV-INDUCED TRANSIENT CELLULAR IMMUNOSUPPRESSION

Authors
RAPP C BERTHOLD H BAUER G
Citation
C. Rapp et al., LOSS AND ANTI-EBNA-1 DURING ACTIVE HEPATITIS-B VIRUS-INFECTION - A DIAGNOSTIC PROBLEM AND INDICATION OF HBV-INDUCED TRANSIENT CELLULAR IMMUNOSUPPRESSION, Medical microbiology letters, 3(5), 1994, pp. 235-243
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
Medical microbiology letters → ACNP
ISSN journal
10184627
Volume
3
Issue
5
Year of publication
1994
Pages
235 - 243
Database
ISI
SICI code
1018-4627(1994)3:5<235:LAADAH>2.0.ZU;2-2
Abstract
Negative anti-EBNA-1 was found more frequently among EBV-seropositive patients with active hepatitis B virus infection than among patients w ith recent HBV infection, HBs antigen carriers, or healthy control per sons. Loss of anti-EBNA-1 during HBV infection points to a suppressive effect of HBV on the cellular immune system. The resulting serodiagno stic problem can be solved when HBV- and EBV-specific antibodies are d etermined in parallel, including avidity determination of VCA-IgG.