AMINO-ACIDS IN EXTRACELLULAR FLUID IN VASOGENIC BRAIN EDEMA

Citation
I. Westergren et al., AMINO-ACIDS IN EXTRACELLULAR FLUID IN VASOGENIC BRAIN EDEMA, Acta neurochirurgica, 1994, pp. 124-127
Citations number
16
Categorie Soggetti
Surgery,Neurosciences
Journal title
ISSN journal
00016268
Year of publication
1994
Supplement
60
Pages
124 - 127
Database
ISI
SICI code
0001-6268(1994):<124:AIEFIV>2.0.ZU;2-U
Abstract
We have investigated if changes in brain dialysate, reflecting alterat ions in brain extracellular composition, can be detected during die de velopment of vasogenic brain edema. The blood-brain barrier was opened by intracarotid infusion of 5 or 10 mg protamine sulphate. The rats w ere killed two hours after opening of the BBB when the brains were mac roscopically edematous, after 10 mg but not 5 mg protamine sulphate. N o significant alterations in the amino acid concentration in die dialy sate were observed after the lower dose. 40 min after infusion of 10 m g protamine, the level of glutamate was significantly increased in the dialysate followed by that of aspartate, glycine, phosphoethanolamine and taurine 10 min later and a further delayed increase in GABA. We c onclude that the development of vasogenic brain edema is associated wi th significant increases in extracellular concentration of excitatory amino acids, of taurine, and of phosphoethanolamine and GABA.