SIMULTANEOUS MEASUREMENT OF BIDIRECTIONAL CAPILLARY-PERMEABILITY, VASCULAR VOLUME, EXTRACELLULAR-SPACE, AND RCBF IN EXPERIMENTAL GLIOMAS AND SURROUNDING EDEMA

Measurements of bidirectional capillary permeability in the ASV tumor model revealed a heterogeneous distibution of transport rates for the small water-soluble molecules which are believed to be the driving for ce in perifocal edema formation. Mean K1 values were 8.1 +/- 5.5 mul/g /min in whole tumor and 18.89 +/- 12.3 mul/g/min in highly permeable a reas. Tumor blood flow ranged between normal white matter and cortex, whereas the plasma vascular space in the tumors was increased as compa red to the normal brain. The size of the extracellular space was depen ding on the regional capillary permeability, underlining the vasogenic nature of peritumoral edema which was capable of being studied using in vivo methods.