EFFECT OF PLATELET-ACTIVATING-FACTOR ANTAGONIST ON BRAIN INJURY IN RATS

The ability of a platelet-activating factor (PAF) antagonist to reduce infarct size has been reported in a animal model of focal brain ische mia. The authors studied the effect of PAF antagonist (TCV-309) on col d brain injury in rats. Twenty-four hours after injury, water content was determined by both drying-weighing and spesific gravimetric techni ques, and ischemic brain damage was assesed with 2,3,5-triphenyltetraz olium chloride in multiple coronal sections. Pretreatment with TCV-309 (lmg/kg) significantly reduced the water content (p < 0.01) and volum e of ischemic damage (p < 0.001) produced by the cold brain injury. Th ese results indicate that PAF antagonist can ameliorate secondary brai n tissue damage following brain injury.