SUCROSE POLYESTER DOES NOT INHIBIT GASTRIC-ACID SECRETION OR STIMULATE CHOLECYSTOKININ RELEASE IN MEN

Replacement of dietary fat by sucrose polyester reduces fat intake. Ho wever, little is known about the effects of sucrose polyester on gastr ointestinal function. To investigate the effect on gastric acid secret ion and on release of cholecystokinin into plasma, we perfused eight h ealthy male volunteers intraduodenally with sucrose polyester, digesti ble fat, or saline on separate days in random order. Intraduodenal per fusion of sucrose polyester did not suppress gastrin-stimulated gastri c acid secretion (-1.8 +/- 6.8%) whereas digestible fat suppressed gas tric acid secretion by 64 +/- 9% (P = 0.001) compared with saline. Suc rose polyester did nor affect plasma cholecystokinin concentrations (- 12.8 +/- 9.3 pmol . 30 min/L) whereas perfusion with digestible fat re sulted in a significant increase (31.7 +/- 9.3 pmol . 30 min/L, P = 0. 017) compared with saline. We conclude that sucrose polyester, in cont rast with digestible fat, does not inhibit gastrin-stimulated gastric acid secretion or stimulate release of cholecystokinin.