HUMAN LYMPHOBLASTOID INTERFERON AS VACCINE ADJUVANT IN CATTLE

Human lymphoblastoid interferon from Namalwa cells was purified for cl inical use by ethanol fractionation, and used as adjuvant of an inacti vated Bovid Herpesvirus I vaccine in calves. In agreement with other i n vitro and in vivo models, low and high interferon doses were shown t o increase and depress the specific antibody response, respectively. T he low, effective interferon dose (100 International Units/kg) also re duced the variability of antibody titres after the fir st vaccine inje ction. This latter dose had apparently no influence on the regulatory T cell circuits, as opposed to the other doses under study.