PRESENTATION, CLINICAL-FEATURES AND OUTCOME IN DIFFERENT PATTERNS OF ATHEROSCLEROTIC RENOVASCULAR DISEASE

Atherosclerotic renovascular disease (ARD) is an increasingly importan t cause of renal failure. However, important features of the clinical presentation are not fully described, and the outcome after interventi on by angioplasty remains controversial. Ninety-four patients with ARD diagnosed at angiography were reviewed. Twenty-four patients were dia betic. Thirty-nine patients had unilateral renal artery stenosis or oc clusion (group A), 28 had bilateral stenosis (group B), and 27 had uni lateral occlusion plus contralateral occlusion or stenosis (group C). Two years after presentation, actuarial patient survival was 96%, 74.3 % and 47.1% in groups A, B and C, respectively (p<0.001 for all differ ences); actuarial renal survival in surviving patients was 97.3%, 82.4 % and 44.7%, respectively (p<0.001 for all differences). Percutaneous transluminal balloon angioplasty (PCTA) was performed in 74 patients. penal function improved in only a minority of cases, but was stable in 73% of nondiabetic patients 12 months after PCTA. Angioplasty was les s effective in diabetic subjects, with only 53.3% having stable renal function at 12 months follow-up. Renal and patient survival were stron gly related to the initial angiographic findings. In nondiabetic subje cts, PCTA resulted in stabilization of renal function for at least one year in nearly three-quarters of cases, which suggests a benefit from intervention in this disease whose natural history is otherwise of pr ogression.