RESULTS OF CONVENTIONAL-DOSE CYTOSINE-ARABINOSIDE AND IDARUBICIN IN ELDERLY PATIENTS WITH ACUTE MYELOID-LEUKEMIA

Conventional-dose Ara-C (200 mg/m(2) d 1-5) combined with idarubicin ( 12 mg/m(2) d 1-3) was employed as remission induction and consolidatio n therapy in 23 elderly AML patients with a median age of 66 years (ra nge, 60-75) with AML according to the FAB criteria (M1 n = 3, M2 n = 1 0, M4 n = 6, M5 n = 2, M6 n = 2), eligible for the study. In seven pat ients earlier MDS had been documented by previous bone marrow aspirate s. The CR rate after one induction course was 65% (15/23). Toxicity wa s acceptable, with four patients dying during the chemotherapy-induced hypoplasia (4/23). Although 80% of the CR patients received two addit ional cycles of Ara-C and idarubicin as consolidation therapy, only tw o patients are still in continuous complete remission more than 12 mon ths after achieving CR. The median disease-free survival of the CR pat ients was 11.5 months and the median survival of the entire group was 10 months. We conclude that conventional dose Ara-C/idarubicin is an e ffective protocol for inducing complete remission in elderly patients with AML, but that consolidation therapy consisting of two courses of the same regimen does not produce a relevant rate of long-term disease -free survival.