The purpose of this study was to correlate the sonographic and histolo
gic findings of focal lesions of the endometrium as depicted by transv
aginal sonography. Sixteen focal endometrial masses were encountered d
uring an 8 month period. The transvaginal sonographic appearance was c
orrelated with findings at surgery or hysteroscopy. All uniformly hype
rechoic endometrial masses were benign endometrial polyps. Five hetero
geneous lesions were complicated endometrial polyps; one of these show
ed a focus of endometrial carcinoma. Four small and uniformly hypoecho
ic lesions were all prolapsed submucosal leiomyomata. Our results show
ed that a well-defined, uniformly hyperechoic mass within the endometr
ial cavity is most suggestive of a benign endometrial polyp. Larger ma
sses with a heterogeneous appearance are nonspecific and warrant furth
er evaluation and biopSy.