Purpose: The purpose of this study was to determine the impact of end-
stage renal disease (ESRD) on the outcome of patients undergoing lower
extremity (LE) amputation. Methods: Hospital charts and vascular surg
ery registry data were reviewed for all patients who underwent LE ampu
tation over a consecutive 56-month period. The results of 84 patients
with ESRD (137 amputations) were compared with 375 patients (442 amput
ations) without ESRD. Results: Hospital mortality rate was significant
ly greater in patients with ESRD than patients without ESRD, 24% versu
s 7% (p = 0.001). Patients with ESRD undergoing minor amputations had
mortality rates three times greater than patients without ESRD undergo
ing major LE amputations. In patients with ESRD requiring bilateral or
unilateral above-knee amputation hospital mortality rates were 43% an
d 38%, respectively. In addition, patients with ESRD were seven times
more likely to undergo bilateral amputation than patients without ESRD
over a mean follow-up period of 17 months. No kidney transplant patie
nts died after amputation. Conclusion: ESRD has a profound negative im
pact on morbidity, mortality, and survival rates after LE amputation.
Attempts at prevention of amputation with aggressive foot care and pat
ient education in this high-risk group should be the focus of therapy.