Four patients were admitted to the medical intensive care unit at King
Khalid University Hospital (KKUH) with overwhelming respiratory failu
re. Extensive investigations revealed serological evidence of Legionel
la infection. Three patients required intubation and mechanical ventil
ation. All patients received erythromycin; rifampin was added to two p
atients. Two patients survived and two patients died. We report, for t
he first time in Saudi Arabia, four cases of Legionella pneumophila wi
th severe respiratory failure.