N. Beaulieu et al., LIQUID-CHROMATOGRAPHIC METHODS FOR DETERMINATION OF TRAZODONE AND RELATED-COMPOUNDS IN DRUG RAW-MATERIALS, Journal of AOAC International, 77(4), 1994, pp. 857-861
Liquid chromatographic methods for the determination of trazodone and
10 related compounds are described. An octylsilane column was used wit
h a mobile phase of tetrahydrofuran-methanol- acetonitrile-0.5% triflu
oroacetic acid (6 + 2 + 6 + 27) and detection at 248 nm. Minimum quant
ifiable amounts of the related compounds were less than 0.05% based on
coefficients of variation of less than 10%. Total impurities in 5 raw
drug materials were less than 1%.