DEHYDROZINGERONE AND ITS ANALOGS AS INHIBITORS OF NONENZYMATIC LIPID-PEROXIDATION

The antioxidant property of dehydrozingerone and its analogs were inve stigated in the ferric-ascorbate induced lipid peroxidation model in r at brain homogenate. All the non phenolic compounds were either inacti ve or less active, while phenolic compounds with substitution at both meta positions were found to be more active than dehydrozingerone. Bas ed on their IC50 values several of these compounds are more potent tha n vitamin E and hence may be of potential use in various diseases caus ed b oxidant stress.