CLONING AND CHARACTERIZATION OF CDNAS CODING FOR HEAVY-CHAINS AND LIGHT-CHAINS OF A MONOCLONAL-ANTIBODY SPECIFIC FOR THE S-ANTIGEN OF HEPATITIS-B VIRUS

Authors
RYU CJ JIN BR CHUNG HK HAN MH HONG HJ
Citation
Cj. Ryu et al., CLONING AND CHARACTERIZATION OF CDNAS CODING FOR HEAVY-CHAINS AND LIGHT-CHAINS OF A MONOCLONAL-ANTIBODY SPECIFIC FOR THE S-ANTIGEN OF HEPATITIS-B VIRUS, Gene, 144(2), 1994, pp. 313-314
Citations number
5
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
144
Issue
2
Year of publication
1994
Pages
313 - 314
Database
ISI
SICI code
0378-1119(1994)144:2<313:CACOCC>2.0.ZU;2-H
Abstract
The nucleotide (nt) sequences encoding the variable regions of the hea vy and light chains of a murine monoclonal antibody (mAb) have been de termined. The mAb recognizes a disulfide-bond-dependent conformational epitope on the hepatitis B virus surface antigen. The sequence analys es revealed that the variable regions of the heavy and light chains ar e members of mouse heavy-chain subgroup II(A) and K light-chain subgro up III, respectively.