EXPERIMENTS DIRECTED TOWARD A TOTAL SYNTHESIS OF DYNEMICIN-A - A SOLUTION TO THE STEREOCHEMICAL PROBLEM

Authors
YOON TY SHAIR MD DANISHEFSKY SJ SHULTE GK
Citation
Ty. Yoon et al., EXPERIMENTS DIRECTED TOWARD A TOTAL SYNTHESIS OF DYNEMICIN-A - A SOLUTION TO THE STEREOCHEMICAL PROBLEM, Journal of organic chemistry, 59(14), 1994, pp. 3752-3754
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
14
Year of publication
1994
Pages
3752 - 3754
Database
ISI
SICI code
0022-3263(1994)59:14<3752:EDTATS>2.0.ZU;2-C
Abstract
The stereochemical issues required for a total synthesis of dynemicin A (1) have been resolved by employing an intramolecular Diels-Alder re action and a diastereoselective addition of a magnesioacetylide to a q uinoline under the influence of methyl chloroformate.