CEREBRAL GLIAL TUMORS AND HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION - MORE THAN A COINCIDENTAL ASSOCIATION

Background. The authors describe the clinical and morphologic patterns in four patients with acquired immune deficiency syndrome (AIDS) who developed intracranial glial tumors. Methods. This retrospective study reports 70 patients at various stages of human immunodeficiency virus -1 (HIV-1) infection who underwent stereotactic brain biopsy for an in tracerebral space-occupying lesion. Results. Of these patients, four h ad glial tumors: one astroblastoma, two astrocytomas, and one glioblas toma. Glial tumors probably arise from a complex interplay of factors; possibilities include the activation of a dominant oncogene or viral inactivation of a tumor suppressor gene by a viral promoter (like the tat protein), impairment of immune defenses (which facilitates the gro wth of astrocytomas in acute lymphoblastic leukemia), production of ce llular growth factors, cytokines, possible infection of glial cells by HIV, and the potentiation of a coinfectious agent. Conclusions. These cases illustrate that glial tumors should be considered in the differ ential diagnosis of brain masses in HIV-1 infection, especially becaus e specific treatment for these tumors is available. Moreover, the occu rrence of glial tumors in AIDS patients is not only an important event from a clinical point of view, but may also have implications for the pathogenesis of tumors in AIDS.